26558253
9783527317905
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Kinases are key regulators of almost every process in the human body. What makes them especially attractive for drug development is their pivotal role in determining whether a cell becomes cancerous or not. It may be said that kinase inhibitors have finally yielded the war-winning weapon in the battle against cancer. The list of cancers treatable with kinase drugs is growing rapidly and currently includes various forms of breast, lung and blood cancer. Edited by the pioneers in the field, this timely guide to this hot topic is the first to cover the entire drug pipeline, from target identification to therapies. On the drug development side it discusses classical medicinal chemistry approaches, as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for first-generation drugs are addressed, with a strong focus on oncology drugs. The result is a ready reference for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.Müller, Gerhard is the author of 'Protein Kinases as Drug Targets', published 2011 under ISBN 9783527317905 and ISBN 3527317902.
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