Part one provides a basic approach to the problems you face in determining optimal therapy, diagnosing, predicting prognosis, and deciding how to protect from potentially harmful exposures. Part two provides many useful cases, and further improves your clinical skills for a thorough grounding in the use of evidence to determine optimal diagnosis treatment and prognosis. With your purchase of the "Users' Guides, you also get a free trial subscription to the "Users' Guides Interactive Web site at www.userguides.org. This Web site includes the full text of "Users' Guides, alternative browsing paths, references that are hyperlinked to NLM PubMed entries, collections of tips and reminders, interactive worksheets, and additional case scenarios. Both the "Manual and "Essentials include a free CD-ROM that contains all the content found in the manual. This sophisticated CD is fully hyperlinked and includes searchable text and graphics; supports electronic outlining, content filtering and full-text searching; and lists alternative content organizations. The "Users' Guides are edited by Drs. Gordon Guyatt and Drummond Rennie, with contributions from more than 50 of the most renowned evidence-based educators and practitioners in the world. The "Users' Guides are published by AMA Press in conjunction with the editors of "JAMA.Guyatt, Gordon is the author of 'Users' Guides to the Medical Literature A Manual for Evidence-Based Clinical Practice' with ISBN 9781579471743 and ISBN 1579471749.