The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. New to the Second Edition The Second Edition retains the goal, format, and presentation style of the first edition but has been extensively updated and revised with the inclusion of many new authors and co-authors. In addition the second edition features: * Pharmacogenetics - Expanded coverage of pharmacogenetics. * Expanded coverage of drug transporters and their role in interactions. * New material added on enzyme induction mechanisms to the chapters on drug metabolism and drug interactions. * New Chapter! A new chapter on Drug Discovery has been added with a focus on oncologic agents. * New coverage of therapeutic antibodies has been added to the chapter on biotechnology products. Hallmark Features * Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy. * Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course. * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study. * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.Atkinson, Arthur J., Jr. is the author of 'Principles of Clinical Pharmacology', published 2006 under ISBN 9780123694171 and ISBN 0123694175.