Egfr Signaling Networks in Cancer Therapy

The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. EGFR Signaling Networks in Cancer Therapy is separated into two sections, the first of which probes the molecular pathways and the intersection of signaling networks, which are frequently deregulated in human cancers, with a view to describing the EGF receptor in a tumor tissue-specific context. The second section illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system and provides compelling information. Probes the molecular pathways and the intersection of signaling networks, which are frequently deregulated in human cancers, Describes EGF receptor in a tumor tissue-specific context, Illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial-to-mesenchymal transition and metastasis. Book jacket.Haley, John D. is the author of 'Egfr Signaling Networks in Cancer Therapy', published 2008 under ISBN 9781588299482 and ISBN 1588299481.