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Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice

Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice

Author: 


ISBN-13: 

9781422306338


ISBN: 

142230633X


Pub Date: 
Publisher:  DIANE Publishing Company
Summary: Bromodichloromethane (BR) is a by-product of the chlorination of drinking water. It has been shown to be carcinogenic at multiple sites in rats & in mice after administration by gavage in corn oil. To further characterize its dose-response relationships for eval. of human risk, BR was nominated for toxicity & carcinogenicity studies in rats & mice by drinking water exposure. Male F344/N rats & female B6C3F1 mice were... exposed to BR in drinking water for 3 weeks or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, L5178Y mouse lymphoma cells, cultured Chinese hamster ovary cells, mouse bone marrow cell, & mouse peripheral blood erythrocytes. None of these studies showed evidence of carcinogenic activity. Illustrations. [read more]

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ISBN-13: 9781422306338


ISBN: 142230633X


Pub Date:
Publisher: DIANE Publishing Company
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