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Structure/Function Analysis of the Amino-Terminal Domain of the Androgen Receptor

Structure/Function Analysis of the Amino-Terminal Domain of the Androgen Receptor

Author: 


ISBN-13: 

9789058673671


ISBN: 

9058673677


Pub Date: 
Publisher:  Leuven University Press
Summary: "This is a Ph.D. dissertation. The amino-terminal domain (NTD) of the androgen receptor (AR) is indispensable for AR transactivation and contains a strong activation function 1. Its activity is affected by coregulators that influence a number of functional properties of AR. The NTD of the AR is 529 aa long and is a complex domain with several functions, namely p160 recruitment, interaction with the LBD, and it contai...ns two transactivation functions Tau-1 And Tau-5. The aim of this study was to obtain a more detailed structure-function analysis of the NTD of the AR. Contents include: Introduction, N/C Interaction in AR-mediated Transactivation, Polyglutamine Stretch, SUMOylation of the AR, Activation Function of the hAR, Discussion, Summary and conclusions, Future Prospects." [read more]

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ISBN-13: 9789058673671


ISBN: 9058673677


Pub Date:
Publisher: Leuven University Press
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