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Structural & Functional Repercussions of Loss of Function & Clinical Mutants of Presenilin

Structural & Functional Repercussions of Loss of Function & Clinical Mutants of Presenilin

Author: 


ISBN-13: 

9789058674593


ISBN: 

9058674592


Pub Date: 
Publisher:  Leuven University Press
Summary: Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) a...re sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work. [read more]

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ISBN-13: 9789058674593


ISBN: 9058674592


Pub Date:
Publisher: Leuven University Press
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