Fundamental Immunology

Preface SECTION I - Introduction UNIT 1 Overview of Immunology Chapter 1 Introduction to the Study of Immunology Overview and Concepts Concepts of Health and Disease Immunity and Immunological Effectors Summary Readings Chapter 2 Cells and Tissues of the Immune System Overview and Concepts Architecture of the Immune System Cells of the Immune System Summary Readings SECTION 2 - Essentials of Immunological Expression UNIT 2 Humoral Immunity Chapter 3 Effectors of Humoral Immunity Overview and Concepts Antigens and Immunogenicity Theories of Antibody Formation Nature of Antibodies Antibody Structure The Antibody-Binding Site Immunoglobulins as Antigens Properties of Immunoglobulin Classes Summary Readings Chapter 4 Antigen-Antibody Reactions Overview and concepts Antigen-Antibody Binding Antibody Affinity Antibody Specificity Detection and Measurement of Antigen-Antibody Interactions Effects of Antigen-Antibody Interactions Summary Readings Chapter 5 Antibody Production, Regulation, and Diversity Overview and Concepts Antibody Production B Cell Differentiation Regulation of Antibody Production Generation of Antibody Diversity Production of Diverse Antibodies Summary Readings Chapter 6 Complement and its Role in Immune Responses Overview and Concepts The Classical Complement Pathway The Alternative or Properdin Pathway Production and Genetics of Complement The Biological Consequences of Complement Activation Complement Deficiencies Immunological Tests for Complement Summary Readings UNIT 3 Cellular Immunity Chapter 7 Histocompatibility Systems Overview and Concepts Background Murine Major Histocompatibility Complex Major Histocompatibility Complex in Humans (HLA) Clinical Significance of the Major Histocompatibility Complex Primary Functions of the Major Histocompatibility Complex Minor Histocompatibility Antigens Summary Readings Chapter 8 Effectors of Nonspecific Cellular Immunity Overview and Concepts Innate Immunity Inflammatory Responses Summary Readings Chapter 9 Effectors of Specific Cellular Immunity Overview and Concepts Cell-Mediated Immune Responses T Cell Differentiation T Cell Receptors for Antigen Cytotoxic T Lymphocytes Delayed-Type Hypersensitivity Lymphocytes Helper T Lymphocytes Suppressor T Lymphocytes Cytokines as Immune Response Modifiers Summary Readings Chapter 10 Immune Tolerance and Suppression Overview and Concepts Regulation of Immune Responses Immunological Tolerance Immunological Suppression Summary Readings SECTION 3 Immunity and Disease UNIT 4 Infectious Diseases and Immunity Chapter 11 Agents of Infectious Disease Overview and Concepts Microparasitic Viruses, Bacteria, and Fungi Host-Parasite Relationships Entry of Microparasites into the Body Events Following Initial Infection by Microparasites Mechanisms of Cell and Tissue Damage Microparasitic Protozoa Macroparasitic Worms Arthropods Summary Readings Chapter 12 Immunity to Infectious Diseases Overview and Concepts Resistance to Viral, Bacterial, and Fungal Microparasites How Microparasites Overcome the Body''s Defenses Resistance to Protistan and Animal Parasites How Protistan and Animal Parasites Elude Immunological Attack Immunization with Vaccines Summary Readings UNIT 5 Damaging and Defective Immune Responses Chapter 13 Hypersensitivity Overview and Concepts Type I Hypersensitivity: Anaphylaxis Type II Hypersensitivity: Cytotoxic Reaction Type III Hypersensitivity: Immune-Complex Deposition Type IV Hypersensitivity: Delayed or Cell Mediated Summary Readings Chapter 14 Immune Deficiencies Overview and Concepts Stem Cell Deficiency Diseases Antibody (B Cell) Immune Deficiency Disorders Cellular (T Cell) Immune Deficiency Disorders Murine Models for B and T Cell Immune Deficiency Disorders Phagocyte Dysfunction Diseases Complement Immune Deficiency Disorders Neuroimmunoendocrinology Aging and the Immune System Summary Readings Chapter 15 Acquired Immune Deficiency Syndrome Overview and Concepts Epidemiology of AIDS Immunobiology of AIDS Animal Models of AIDS Treatment of AIDS Vaccines Diagnostic Evaluation of HIV Summary Readings Chapter 16 Autoimmunity Overview and Concepts Theories of Breakdown in Self-Tolerance Mechanism of Tissue Damage in Autoimmune Diseases Diagnostic Testing Genetic Factors in Autoimmune Diseases Criteria for Classification as an Autoimmune Disease Selected Autoimmune Diseases: Organ Specific Selected Autoimmune Diseases: Systemic Diseases Experimental Models for Autoimmune Disorders Summary Readings UNIT 6 Cancer and Transplantation Chapter 17 Cancer Overview and Concepts Distribution and Causes of Cancer Tumors Oncogenesis Metastasis Cancer Therapy Cancer Prevention Summary Readings Chapter 18 Tumor Immunology Overview and Concepts Theory of Immune Surveillance Host Immune Responses to Tumors Tumor Antigens Tumor Escape Mechanisms Dialog Between Tumor Cells and the Immune System Immune Diagnosis of Tumors Tumor Immunotherapy: Nonspecific Treatments Tumor Immunotherapy: Antigen-Specific Treatments Cancer of the Immune System Summary Readings Chapter 19 Transplantation Immunology Overview and Concepts Human Transplantation Antigens Histocompatibility Testing Rejection Mechanism Types of Transplants Graft-vs-Host Reactions Prevention of Graft Rejection The Fetus as a Graft Summary Readings SECTION 4 - Ontogeny and Phylogeny of Immunity UNIT 7 Developmental and Comparative Immunology Chapter 20 Development of Immunity Overview and Concepts Immunity in Reproduction Changing Status of Immunity Throughout Life Development of Hemopoietic and Lymphoid Organs Development of Humoral Immunity Development of Cellular Immunity Development of the Complement System Summary Readings Chapter 21 Comparative Immunobiology Overview and Concepts Defense Mechanisms of Invertebrates Immunity in Nonmammalian Vertebrates Phylogeny of Immunoglobulins and Related Molecules Phylogeny of Complement Phylogeny of Lymphoid Cells and Organs Phylogeny of Cell-Mediated Immunity Summary Readings Appendix A Abbreviations and Acronyms Appendix B Milestones in the History of Immunology Appendix C Characterization of Immune Status and Function Appendix D Human and Murine Cell-Surface Antigens Glossary Index Plates Inside Cover TablesLombard, Mary F. is the author of 'Fundamental Immunology' with ISBN 9780072357479 and ISBN 0072357479.